Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner.

Galloway, S M; McNatty, K P; Cambridge, L M; Laitinen, M P; Juengel, J L; Jokiranta, T S; McLaren, R J; Luiro, K; Dodds, K G; Montgomery, G W; Beattie, A E; Davis, G H; Ritvos, O

Galloway, S M; McNatty, K P; Cambridge, L M; Laitinen, M P; Juengel, J L; Jokiranta, T S; McLaren, R J; Luiro, K; Dodds, K G; Montgomery, G W; Beattie, A E; Davis, G H; Ritvos, O.

Affiliation

Galloway SM; AgResearch Molecular Biology Unit, and Centre for Gene Research, Department of Biochemistry, University of Otago, Dunedin, New Zealand. galloways@agresearch.cri.nz

Nat Genet ; 25(3): 279-83, 2000 Jul.

Article in En | MEDLINE | ID: mdl-10888873

Subject(s)

Bone Morphogenetic Proteins/genetics; Growth Substances/genetics; Infertility, Female/genetics; Intercellular Signaling Peptides and Proteins; Mutation; Ovulation/physiology; X Chromosome; Amino Acid Sequence; Animals; Base Sequence; Bone Morphogenetic Protein 15; Bone Morphogenetic Proteins/chemistry; Chromosome Mapping; DNA, Complementary; Female; Growth Differentiation Factor 9; Growth Substances/chemistry; Humans; Male; Mice; Models, Molecular; Molecular Sequence Data; Oocytes/metabolism; Pedigree; Protein Conformation; Sheep

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Collection: 01-internacional Database: MEDLINE Main subject: Ovulation / X Chromosome / Growth Substances / Bone Morphogenetic Proteins / Intercellular Signaling Peptides and Proteins / Infertility, Female / Mutation Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2000 Type: Article Affiliation country: New Zealand

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