Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based drug design.

Zeslawska, E; Schweinitz, A; Karcher, A; Sondermann, P; Sperl, S; Stürzebecher, J; Jacob, U

Zeslawska, E; Schweinitz, A; Karcher, A; Sondermann, P; Sperl, S; Stürzebecher, J; Jacob, U.

Affiliation

Zeslawska E; Max-Planck-Institut für Biochemie, Abteilung Strukturforschung, Martinsried, Am Klopferspitz 18a, D-82152, Germany.

J Mol Biol ; 301(2): 465-75, 2000 Aug 11.

Article in En | MEDLINE | ID: mdl-10926521

Subject(s)

Serine Proteinase Inhibitors/chemistry; Urokinase-Type Plasminogen Activator/chemistry; Amiloride/chemistry; Amino Acid Sequence; Benzamidines/chemistry; Crystallography, X-Ray; Drug Design; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Sequence Alignment; Structure-Activity Relationship; Trypsin/chemistry

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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Urokinase-Type Plasminogen Activator / Serine Proteinase Inhibitors Language: En Journal: J Mol Biol Year: 2000 Type: Article Affiliation country: Germany

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