Hexarelin exhibits protective activity against cardiac ischaemia in hearts from growth hormone-deficient rats.
Growth Horm IGF Res
; 8 Suppl B: 149-52, 1998 Apr.
Article
in En
| MEDLINE
| ID: mdl-10990152
ABSTRACT
Male rats were treated with growth hormone (GH)-releasing hormone antiserum to induce selective GH deficiency. The chronic administration of hexarelin to these GH-deficient rats had a pronounced protective effect against ischaemic and post-ischaemic ventricular dysfunction. Hexarelin prevented hyper-responsiveness of the coronary vascular bed to angiotensin II and also prevented the reduction in generation of 6-keto-prostaglandin F1alpha in perfused hearts from GH-deficient rats. The most plausible interpretation of these findings is that hexarelin acts via stimulation of specific cardiac and vascular receptors, triggering currently unknown cytoprotective mechanisms that are responsible for resistance to ischaemic insults and for the preservation of the integrity of the endothelial vasodilation function.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oligopeptides
/
Growth Hormone
/
Myocardial Ischemia
/
Cytoprotection
/
Heart Ventricles
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Growth Horm IGF Res
Journal subject:
ENDOCRINOLOGIA
Year:
1998
Type:
Article
Affiliation country:
Italy