RNA aptamers as pathway-specific MAP kinase inhibitors.

Seiwert, S D; Stines Nahreini, T; Aigner, S; Ahn, N G; Uhlenbeck, O C

Seiwert, S D; Stines Nahreini, T; Aigner, S; Ahn, N G; Uhlenbeck, O C.

Affiliation

Seiwert SD; Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309-0215, USA. scott.siewert@colorado.edu

Chem Biol ; 7(11): 833-43, 2000 Nov.

Article in En | MEDLINE | ID: mdl-11094337

Subject(s)

Combinatorial Chemistry Techniques/methods; DNA-Binding Proteins; MAP Kinase Signaling System/physiology; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Proto-Oncogene Proteins; RNA/metabolism; Transcription Factors; Animals; Base Sequence; Gene Library; Genes, Reporter; Humans; Kinetics; Ligands; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3; Models, Biological; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Phosphorylation; Potassium Channels/genetics; Potassium Channels/metabolism; Protein Structure, Tertiary; RNA/chemistry; Rats; Recombinant Fusion Proteins/metabolism; Substrate Specificity; ets-Domain Protein Elk-1

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / RNA / Proto-Oncogene Proteins / Mitogen-Activated Protein Kinase 1 / Mitogen-Activated Protein Kinases / MAP Kinase Signaling System / Combinatorial Chemistry Techniques / DNA-Binding Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Chem Biol Journal subject: BIOLOGIA / BIOQUIMICA / QUIMICA Year: 2000 Type: Article Affiliation country: United States

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