Teratogenic and toxic effects of alcohol ethoxylate and alcohol ethoxy sulfate surfactants on Xenopus laevis embryos and tadpoles.
Ecotoxicol Environ Saf
; 48(2): 170-7, 2001 Feb.
Article
in En
| MEDLINE
| ID: mdl-11161691
ABSTRACT
The two surfactants tested, an alcohol ethoxylate (AE) and an alcohol ethoxy sulfate (AES), demonstrate both teratogenic and toxic effects in Xenopus laevis embryos and tadpoles. From acute tests and observations of malformations under light and electron microscopy, the AES produced less teratogenic and toxic effects than the AE, from which it differs only by the presence of a sulfate in the hydrophilic group of the molecule. The 72-h LC(50) was 4.59 mg/L for the AE and 6.75 g/L for the AES. The tissues most affected were the epithelia, particularly of the gills. As the AE exhibited ultrastructural alterations of mitochondria and narcotic effects, O(2) consumption was studied in treated tadpoles; results indicated collapse of the electrochemical gradient in mitochondria.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sulfuric Acid Esters
/
Surface-Active Agents
/
Teratogens
/
Alcohols
/
Embryo, Nonmammalian
/
Larva
Limits:
Animals
Language:
En
Journal:
Ecotoxicol Environ Saf
Year:
2001
Type:
Article
Affiliation country:
Italy