Vestibular and cochlear toxicity of aminoglycosides--a review.
Acta Otolaryngol
; 120(8): 904-11, 2000 Oct.
Article
in En
| MEDLINE
| ID: mdl-11200584
ABSTRACT
Recently, there have been many reports describing the efficacy of intratympanic aminoglycoside injection for the treatment of intractable vertigo in patients with Ménière's disease. However, the number of injections and the amount of drug injected varies, with concomitant variation in the side-effect of hearing deterioration. To identify drugs that are more selectively vestibulotoxic, we have reviewed the ototoxicity of aminoglycosides, focusing on differences between vestibulo- and cochleotoxicity. At present, the basis for the different effects of each drug is unknown. The mechanisms of vestibulo- and cochleotoxicity are deemed worthy of further study.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cochlear Diseases
/
Vestibular Diseases
/
Aminoglycosides
Limits:
Humans
Language:
En
Journal:
Acta Otolaryngol
Year:
2000
Type:
Article
Affiliation country:
Japan