Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine.

Evans, W E; Hon, Y Y; Bomgaars, L; Coutre, S; Holdsworth, M; Janco, R; Kalwinsky, D; Keller, F; Khatib, Z; Margolin, J; Murray, J; Quinn, J; Ravindranath, Y; Ritchey, K; Roberts, W; Rogers, Z R; Schiff, D; Steuber, C; Tucci, F; Kornegay, N; Krynetski, E Y; Relling, M V

Evans, W E; Hon, Y Y; Bomgaars, L; Coutre, S; Holdsworth, M; Janco, R; Kalwinsky, D; Keller, F; Khatib, Z; Margolin, J; Murray, J; Quinn, J; Ravindranath, Y; Ritchey, K; Roberts, W; Rogers, Z R; Schiff, D; Steuber, C; Tucci, F; Kornegay, N; Krynetski, E Y; Relling, M V.

Affiliation

Evans WE; St Jude Children's Research Hospital and University of Tennessee, Memphis 38101-0318, USA. william.evans@stjude.org

J Clin Oncol ; 19(8): 2293-301, 2001 Apr 15.

Article in En | MEDLINE | ID: mdl-11304783

Subject(s)

Antimetabolites, Antineoplastic/adverse effects; Azathioprine/adverse effects; Mercaptopurine/adverse effects; Methyltransferases/deficiency; Methyltransferases/genetics; Polymorphism, Restriction Fragment Length; Thrombocytopenia/chemically induced; Adolescent; Adult; Child; Child, Preschool; Female; Genotype; Hospitalization; Humans; Infant; Male; Methyltransferases/metabolism; Neoplasms/drug therapy; Phenotype; Platelet Transfusion; Risk Factors; Thrombocytopenia/genetics

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Azathioprine / Thrombocytopenia / Polymorphism, Restriction Fragment Length / Mercaptopurine / Methyltransferases / Antimetabolites, Antineoplastic Type of study: Etiology_studies / Risk_factors_studies Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: J Clin Oncol Year: 2001 Type: Article Affiliation country: United States

Search on Google

XML

PubMed Links