HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme.

Miyata, N; Taniguchi, K; Seki, T; Ishimoto, T; Sato-Watanabe, M; Yasuda, Y; Doi, M; Kametani, S; Tomishima, Y; Ueki, T; Sato, M; Kameo, K

Miyata, N; Taniguchi, K; Seki, T; Ishimoto, T; Sato-Watanabe, M; Yasuda, Y; Doi, M; Kametani, S; Tomishima, Y; Ueki, T; Sato, M; Kameo, K.

Affiliation

Miyata N; Medicinal Research Laboratories, Taisho Pharmaceutical Co. Ltd., 1-403 Yoshino-cho, Ohmiya, Saitama 330-8530, Japan. s14307@ccm.taisho.co.jp

Br J Pharmacol ; 133(3): 325-9, 2001 Jun.

Article in En | MEDLINE | ID: mdl-11375247

Subject(s)

Amidines/pharmacology; Arachidonic Acid/metabolism; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors/pharmacology; Hydroxyeicosatetraenoic Acids/metabolism; Steroid 16-alpha-Hydroxylase; Amidines/chemistry; Animals; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6/metabolism; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System/metabolism; Enzyme Inhibitors/chemistry; Humans; Kidney/drug effects; Kidney/enzymology; Kidney/metabolism; Male; Microsomes/drug effects; Microsomes/enzymology; Microsomes/metabolism; Mixed Function Oxygenases/antagonists & inhibitors; Mixed Function Oxygenases/metabolism; Rats; Rats, Inbred SHR; Steroid Hydroxylases/antagonists & inhibitors; Steroid Hydroxylases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aryl Hydrocarbon Hydroxylases / Hydroxyeicosatetraenoic Acids / Arachidonic Acid / Steroid 16-alpha-Hydroxylase / Enzyme Inhibitors / Cytochrome P-450 Enzyme Inhibitors / Amidines Limits: Animals / Humans / Male Language: En Journal: Br J Pharmacol Year: 2001 Type: Article Affiliation country: Japan

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