Promoter hypermethylation: a common cause of reduced p16(INK4a) expression in uveal melanoma.

van der Velden, P A; Metzelaar-Blok, J A; Bergman, W; Monique, H; Hurks, H; Frants, R R; Gruis, N A; Jager, M J

van der Velden, P A; Metzelaar-Blok, J A; Bergman, W; Monique, H; Hurks, H; Frants, R R; Gruis, N A; Jager, M J.

Affiliation

van der Velden PA; Section Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, 2333 AL Leiden, the Netherlands.

Cancer Res ; 61(13): 5303-6, 2001 Jul 01.

Article in En | MEDLINE | ID: mdl-11431374

Subject(s)

Cyclin-Dependent Kinase Inhibitor p16/genetics; DNA Methylation; Gene Silencing; Melanoma/genetics; Promoter Regions, Genetic; Uveal Neoplasms/genetics; Adult; Aged; Aged, 80 and over; Azacitidine/analogs & derivatives; Azacitidine/pharmacology; CpG Islands/physiology; Cyclin-Dependent Kinase Inhibitor p16/biosynthesis; DNA Methylation/drug effects; DNA, Neoplasm/genetics; DNA, Neoplasm/metabolism; Decitabine; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Melanoma/metabolism; Melanoma/pathology; Middle Aged; RNA, Messenger/biosynthesis; RNA, Messenger/genetics; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured/drug effects; Uveal Neoplasms/metabolism; Uveal Neoplasms/pathology

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Collection: 01-internacional Database: MEDLINE Main subject: Uveal Neoplasms / Promoter Regions, Genetic / DNA Methylation / Cyclin-Dependent Kinase Inhibitor p16 / Gene Silencing / Melanoma Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Cancer Res Year: 2001 Type: Article Affiliation country: Netherlands

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