Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.

Ma, Z; Morris, S W; Valentine, V; Li, M; Herbrick, J A; Cui, X; Bouman, D; Li, Y; Mehta, P K; Nizetic, D; Kaneko, Y; Chan, G C; Chan, L C; Squire, J; Scherer, S W; Hitzler, J K

Ma, Z; Morris, S W; Valentine, V; Li, M; Herbrick, J A; Cui, X; Bouman, D; Li, Y; Mehta, P K; Nizetic, D; Kaneko, Y; Chan, G C; Chan, L C; Squire, J; Scherer, S W; Hitzler, J K.

Affiliation

Ma Z; Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Nat Genet ; 28(3): 220-1, 2001 Jul.

Article in En | MEDLINE | ID: mdl-11431691

ABSTRACT

t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.

Subject(s)

DNA-Binding Proteins/genetics; Leukemia, Megakaryoblastic, Acute/genetics; Oncogene Proteins, Fusion/genetics; RNA-Binding Proteins/genetics; Translocation, Genetic; Chromosomes, Human, Pair 1/genetics; Chromosomes, Human, Pair 22/genetics; Humans; Molecular Sequence Data; Trans-Activators

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Collection: 01-internacional Database: MEDLINE Main subject: Translocation, Genetic / Leukemia, Megakaryoblastic, Acute / Oncogene Proteins, Fusion / RNA-Binding Proteins / DNA-Binding Proteins Limits: Humans Language: En Journal: Nat Genet Journal subject: GENETICA MEDICA Year: 2001 Type: Article Affiliation country: United States

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