The controversies and pitfalls in modeling normal tissue radiation injury/damage.
Semin Radiat Oncol
; 11(3): 210-4, 2001 Jul.
Article
in En
| MEDLINE
| ID: mdl-11447577
ABSTRACT
Highly conformal fields have become achievable in routine clinical practice. The optimal shape of the resultant dose distributions depends on information that is not currently available. This missing information is the dose-volume response of the normal tissues at risk. These functions are now the subject of aggressive research. The research involves collecting the dose-response data, modeling the dose-response function, and fitting the models to the data. The controversies addressed here influence the selection of the biomathematical model that one might use to describe such a function. The form that the dose-volume response function takes depends on the nature of the volume effect. The nature of the volume effect for a given radiation response is the subject of considerable debate. Related to this debate, this report addresses the existence of the volume effect, the existence of a threshold volume, and the existence of functional subunits. The pitfalls relate to the problems in accurate determination and application of the dose-response functions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radiation Injuries
/
Models, Biological
Limits:
Humans
Language:
En
Journal:
Semin Radiat Oncol
Journal subject:
NEOPLASIAS
/
RADIOLOGIA
Year:
2001
Type:
Article
Affiliation country:
United States