The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2.

Schimmer, A D; Hedley, D W; Chow, S; Pham, N A; Chakrabartty, A; Bouchard, D; Mak, T W; Trus, M R; Minden, M D

Schimmer, A D; Hedley, D W; Chow, S; Pham, N A; Chakrabartty, A; Bouchard, D; Mak, T W; Trus, M R; Minden, M D.

Affiliation

Schimmer AD; University Health Network, Princess Margaret Hospital, 610 University Ave., Toronto, Ontario M5G 2M9, Canada.

Cell Death Differ ; 8(7): 725-33, 2001 Jul.

Article in En | MEDLINE | ID: mdl-11464217

Subject(s)

Apoptosis; Carrier Proteins/chemistry; Carrier Proteins/metabolism; Homeodomain Proteins/metabolism; Nuclear Proteins; Protein Sorting Signals/physiology; Proto-Oncogene Proteins c-bcl-2/physiology; Transcription Factors; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Amino Acid Sequence; Antennapedia Homeodomain Protein; Carrier Proteins/genetics; Caspase 3; Caspase Inhibitors; Caspases/metabolism; Circular Dichroism; Enzyme Activation; Female; HeLa Cells; Homeodomain Proteins/chemistry; Humans; Membrane Potentials; Mitochondria/metabolism; Molecular Sequence Data; Mutation; Peptide Fragments/chemistry; Peptide Fragments/metabolism; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Reactive Oxygen Species/metabolism; Recombinant Fusion Proteins/chemistry; Recombinant Fusion Proteins/metabolism; Structure-Activity Relationship; Surface Plasmon Resonance; bcl-Associated Death Protein

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Protein Sorting Signals / Nuclear Proteins / Carrier Proteins / Apoptosis / Homeodomain Proteins / Proto-Oncogene Proteins c-bcl-2 Limits: Female / Humans Language: En Journal: Cell Death Differ Year: 2001 Type: Article Affiliation country: Canada

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