Germline RET 634 mutation positive MEN 2A-related C-cell hyperplasias have genetic features consistent with intraepithelial neoplasia.

Diaz-Cano, S J; de Miguel, M; Blanes, A; Tashjian, R; Wolfe, H J

Diaz-Cano, S J; de Miguel, M; Blanes, A; Tashjian, R; Wolfe, H J.

Affiliation

Diaz-Cano SJ; Department of Pathology, Tufts University-New England Medical Center, Boston, Massachusetts 02111, USA. s.j.diaz-cano@mds.qmw.ac.uk

J Clin Endocrinol Metab ; 86(8): 3948-57, 2001 Aug.

Article in En | MEDLINE | ID: mdl-11502837

Subject(s)

Drosophila Proteins; Germ-Line Mutation; Multiple Endocrine Neoplasia Type 2a/genetics; Proto-Oncogene Proteins/genetics; Receptor Protein-Tyrosine Kinases/genetics; Amino Acid Substitution; Antigens, Nuclear; Autoantigens/genetics; Calcitonin/blood; Carcinoma, Medullary/genetics; Carcinoma, Medullary/surgery; Cysteine; DNA Primers; Female; Focal Epithelial Hyperplasia/genetics; Genes, Retinoblastoma; Humans; Ki-67 Antigen; Loss of Heterozygosity; Multiple Endocrine Neoplasia Type 2a/complications; Multiple Endocrine Neoplasia Type 2a/pathology; Nerve Tissue Proteins/genetics; Neurofibromin 1; Nuclear Proteins/genetics; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-ret; Thyroid Diseases/complications; Thyroid Diseases/genetics; Thyroid Diseases/surgery; Thyroid Neoplasms/genetics; Thyroid Neoplasms/surgery; Thyroidectomy; Tyrosine

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Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins / Receptor Protein-Tyrosine Kinases / Germ-Line Mutation / Multiple Endocrine Neoplasia Type 2a / Drosophila Proteins Limits: Female / Humans Language: En Journal: J Clin Endocrinol Metab Year: 2001 Type: Article Affiliation country: United States

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