Targeting superoxide dismutase to renal proximal tubule cells inhibits nephrotoxicity of cisplatin and increases the survival of cancer-bearing mice.
Cancer Lett
; 171(2): 133-8, 2001 Oct 10.
Article
in En
| MEDLINE
| ID: mdl-11520596
ABSTRACT
Because cis-diamminedichloroplatinum(II) (cisplatin) which generates reactive oxygen species induces renal dysfunction, administration of a large dose for killing cancer cells is highly limited. We recently synthesized a cationic superoxide dismutase (SOD) (hexamethylenediamine-conjugated SOD, AH-SOD) which rapidly accumulates in renal proximal tubule cells and inhibits oxidative injury of the kidney. Treatment of Ehrlich ascites tumor cells (EATC)-bearing mice with cisplatin sufficient for killing tumor cells increased their motality. The motality of cisplatin-treated EATC-bearing mice was markedly decreased by AH-SOD. These results suggest that targeting SOD to renal proximal tubule cells might permit the administration of high doses of cisplatin and related anticancer agents without causing renal injury.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Superoxide Dismutase
/
Cisplatin
/
Kidney Diseases
/
Kidney Tubules, Proximal
/
Antineoplastic Agents
Limits:
Animals
Language:
En
Journal:
Cancer Lett
Year:
2001
Type:
Article
Affiliation country:
Japan