Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics.

Melov, S; Doctrow, S R; Schneider, J A; Haberson, J; Patel, M; Coskun, P E; Huffman, K; Wallace, D C; Malfroy, B

Melov, S; Doctrow, S R; Schneider, J A; Haberson, J; Patel, M; Coskun, P E; Huffman, K; Wallace, D C; Malfroy, B.

Affiliation

Melov S; Buck Institute for Age Research, Novato, California 94945, USA. smelov@buckinstitute.org

J Neurosci ; 21(21): 8348-53, 2001 Nov 01.

Article in En | MEDLINE | ID: mdl-11606622

Subject(s)

Antioxidants/administration & dosage; Free Radical Scavengers/administration & dosage; Neurodegenerative Diseases/drug therapy; Neurodegenerative Diseases/enzymology; Superoxide Dismutase/deficiency; Animals; Antioxidants/chemistry; Catalase; Catalysis; Disease Progression; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethylenediamines/administration & dosage; Ethylenediamines/chemistry; Free Radical Scavengers/chemistry; Injections, Intraperitoneal; Lipids/chemistry; Metalloporphyrins/administration & dosage; Mice; Mice, Knockout; Mitochondria/drug effects; Mitochondria/pathology; Neurodegenerative Diseases/genetics; Neurodegenerative Diseases/pathology; Organometallic Compounds/administration & dosage; Organometallic Compounds/chemistry; Oxidative Stress/drug effects; Phenotype; Salicylates/administration & dosage; Salicylates/chemistry; Superoxide Dismutase/genetics; Survival Rate

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Superoxide Dismutase / Free Radical Scavengers / Neurodegenerative Diseases / Antioxidants Limits: Animals Language: En Journal: J Neurosci Year: 2001 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google