An antisense construct of full-length human RAD50 cDNA confers sensitivity to ionizing radiation and alkylating agents on human cell lines.

Kim, Young Chul; Koh, Jeong Tae; Shin, Boo Ahn; Ahn, Kyu Youn; Choi, Bong Kyu; Kim, Chang Guhn; Kim, Kyung Keun

Kim, Young Chul; Koh, Jeong Tae; Shin, Boo Ahn; Ahn, Kyu Youn; Choi, Bong Kyu; Kim, Chang Guhn; Kim, Kyung Keun.

Affiliation

Kim YC; Department of Diagnostic Radiology, Chosun University Hospital, Kwangju 501-759, South Korea.

Radiat Res ; 157(1): 19-25, 2002 Jan.

Article in En | MEDLINE | ID: mdl-11754637

Subject(s)

Alkylating Agents/pharmacology; DNA Repair Enzymes; DNA Repair/genetics; DNA, Complementary/genetics; DNA-Binding Proteins/physiology; Gamma Rays/adverse effects; Oligodeoxyribonucleotides, Antisense/genetics; Radiation Tolerance/genetics; Acid Anhydride Hydrolases; Carcinoma, Hepatocellular/pathology; Carcinoma, Squamous Cell/pathology; Cell Line/drug effects; Cell Line/radiation effects; DNA Damage; DNA, Neoplasm/drug effects; DNA, Neoplasm/radiation effects; DNA-Binding Proteins/antagonists & inhibitors; DNA-Binding Proteins/biosynthesis; DNA-Binding Proteins/genetics; Humans; Kidney/cytology; Liver Neoplasms/pathology; MRE11 Homologue Protein; Methyl Methanesulfonate/pharmacology; Mitomycin/pharmacology; Oligodeoxyribonucleotides, Antisense/pharmacology; Transfection; Tumor Cells, Cultured/drug effects; Tumor Cells, Cultured/radiation effects; Ultraviolet Rays/adverse effects

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Collection: 01-internacional Database: MEDLINE Main subject: Radiation Tolerance / DNA, Complementary / Oligodeoxyribonucleotides, Antisense / DNA Repair Enzymes / DNA-Binding Proteins / DNA Repair / Alkylating Agents / Gamma Rays Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Radiat Res Year: 2002 Type: Article Affiliation country: South Korea

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