GABARAP and GABA(A) receptor clustering.

Phillips, William D; Froehner, Stanley C

Phillips, William D; Froehner, Stanley C.

Affiliation

Phillips WD; Department of Physiology, University of Sydney, NSW 2006, Australia.

Neuron ; 33(1): 4-6, 2002 Jan 03.

Article in En | MEDLINE | ID: mdl-11779472

ABSTRACT

ABSTRACT

Coyle et al. (2002), in this issue of Neuron, reveal the crystal structure for the GABA(A) receptor binding protein, GABARAP. They show GABARAP can switch from a monomer to an extended linear polymer form that may function to assemble microtubules during the intracellular trafficking or postsynaptic clustering of GABA(A) receptors.

Subject(s)

Microtubule-Associated Proteins/chemistry; Microtubules/metabolism; Neural Inhibition/physiology; Protein Transport/physiology; Receptors, GABA-A/metabolism; Synaptic Transmission/physiology; Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Carrier Proteins/metabolism; Humans; Membrane Proteins/metabolism; Mice; Protein Structure, Tertiary/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, GABA-A / Synaptic Transmission / Protein Transport / Microtubule-Associated Proteins / Microtubules / Neural Inhibition Limits: Animals / Humans Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2002 Type: Article Affiliation country: Australia

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