Accelerated cardiomyopathy in mice with overexpression of cardiac G(s)alpha and a missense mutation in the alpha-myosin heavy chain.

Hardt, Stefan E; Geng, Yong-Jian; Montagne, Olivier; Asai, Kuniya; Hong, Chull; Yang, Gui Ping; Bishop, Sanford P; Kim, Song-Jung; Vatner, Dorothy E; Seidman, Christine E; Seidman, J G; Homcy, Charles J; Vatner, Stephen F

Hardt, Stefan E; Geng, Yong-Jian; Montagne, Olivier; Asai, Kuniya; Hong, Chull; Yang, Gui Ping; Bishop, Sanford P; Kim, Song-Jung; Vatner, Dorothy E; Seidman, Christine E; Seidman, J G; Homcy, Charles J; Vatner, Stephen F.

Affiliation

Hardt SE; Cardiovascular Research Institute, Department of Cell Biology, University of Medicine and Dentistry New Jersey, New Jersey Medical School, Newark, USA.

Circulation ; 105(5): 614-20, 2002 Feb 05.

Article in En | MEDLINE | ID: mdl-11827928

Subject(s)

Cardiomyopathy, Hypertrophic, Familial/genetics; Cardiomyopathy, Hypertrophic, Familial/metabolism; GTP-Binding Protein alpha Subunits, Gs/metabolism; Mutation, Missense; Myosin Heavy Chains/genetics; Animals; Body Weight; Cardiomyopathy, Hypertrophic, Familial/pathology; Cell Separation; Crosses, Genetic; Disease Models, Animal; Disease Progression; Echocardiography; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism; GTP-Binding Protein alpha Subunits, Gs/genetics; Heart Rate/genetics; In Vitro Techniques; Mice; Mice, Transgenic; Myocardial Contraction/genetics; Myocardium/metabolism; Myocardium/pathology; Myosin Heavy Chains/metabolism; Organ Size; Stroke Volume/genetics; Survival Rate; Ventricular Function, Left/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Myosin Heavy Chains / GTP-Binding Protein alpha Subunits, Gs / Mutation, Missense / Cardiomyopathy, Hypertrophic, Familial Limits: Animals Language: En Journal: Circulation Year: 2002 Type: Article Affiliation country: United States

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