Constitutive expression of angiopoietin-1 and -2 and modulation of their expression by inflammatory cytokines in rheumatoid arthritis synovial fibroblasts.

Scott, Boyd B; Zaratin, Paola F; Colombo, Antonio; Hansbury, Michael J; Winkler, James D; Jackson, Jeffrey R

Scott, Boyd B; Zaratin, Paola F; Colombo, Antonio; Hansbury, Michael J; Winkler, James D; Jackson, Jeffrey R.

Affiliation

Scott BB; Department of Neurology, GlaxoSmithKline SpA, Milano, Italy.

J Rheumatol ; 29(2): 230-9, 2002 Feb.

Article in En | MEDLINE | ID: mdl-11838839

Subject(s)

Arthritis, Rheumatoid/metabolism; Cytokines/physiology; Fibroblasts/metabolism; Membrane Glycoproteins/metabolism; Proteins/metabolism; Synovial Membrane/metabolism; Angiopoietin-1; Angiopoietin-2; Cells, Cultured; Culture Media, Conditioned/pharmacology; Cytokines/pharmacology; Endothelium, Vascular/cytology; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; Fibroblasts/drug effects; Gene Expression; Humans; Ligands; Membrane Glycoproteins/genetics; Polymerase Chain Reaction; Proteins/genetics; RNA, Messenger/biosynthesis; Receptor Protein-Tyrosine Kinases/metabolism; Receptor, TIE-2; Synovial Membrane/drug effects; Transforming Growth Factor beta/pharmacology; Transforming Growth Factor beta/physiology; Tumor Necrosis Factor-alpha/pharmacology; Tumor Necrosis Factor-alpha/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Synovial Membrane / Membrane Glycoproteins / Proteins / Cytokines / Fibroblasts Limits: Humans Language: En Journal: J Rheumatol Year: 2002 Type: Article Affiliation country: Italy

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