Modulation of atopy patch test reactions by topical treatment of human skin with a fatty acid-rich emollient.
Skin Pharmacol Appl Skin Physiol
; 15(2): 100-4, 2002.
Article
in En
| MEDLINE
| ID: mdl-11867966
ABSTRACT
Measures directed at improving the skin barrier function are thought to be effective in preventing reexacerbation of atopic dermatitis, but direct proof of a prophylactic effect of emollients has been elusive. In the present study, the atopy patch test has been employed as a model for the initiation phase of atopic dermatitis in order to assess whether pretreatment of non-lesional skin with a fatty acid-rich emollient (Eucerin Omega Creme) has a prophylactic effect in patients with atopic dermatitis. Pretreatment of test sites with Eucerin Omega Creme either prevented or diminished the development of eczema, as compared with untreated control test sites in the same patients (n = 38). These studies indicate that the use of fatty acid-rich emollients prevents the development of atopic eczema. They also demonstrate that the atopy patch test can be used to assess the capacity of a given regimen to exert prophylactic effects in this disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin
/
Dermatitis, Atopic
/
Emollients
/
Fatty Acids
Limits:
Adult
/
Humans
/
Middle aged
Language:
En
Journal:
Skin Pharmacol Appl Skin Physiol
Journal subject:
DERMATOLOGIA
/
FARMACOLOGIA
/
FISIOLOGIA
Year:
2002
Type:
Article
Affiliation country:
Germany