4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.

Russo, James; Barnes, Annette; Berger, Katie; Desgrosellier, Jay; Henderson, Jennifer; Kanters, Ana; Merkov, Lubo

Russo, James; Barnes, Annette; Berger, Katie; Desgrosellier, Jay; Henderson, Jennifer; Kanters, Ana; Merkov, Lubo.

Affiliation

Russo J; Department of Chemistry, Whitman College, Walla Walla, WA 99362, USA. russo@whitman.edu

BMC Pharmacol ; 2: 4, 2002.

Article in En | MEDLINE | ID: mdl-11872149

Subject(s)

Benzaldehydes/pharmacology; Cell Differentiation/drug effects; Retinaldehyde/metabolism; Tretinoin/metabolism; Aldehyde Dehydrogenase/metabolism; Aldehyde Dehydrogenase 1 Family; Animals; HL-60 Cells; Humans; Isoenzymes/metabolism; Mice; Oxidation-Reduction/drug effects; Retinal Dehydrogenase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinaldehyde / Tretinoin / Benzaldehydes / Cell Differentiation Limits: Animals / Humans Language: En Journal: BMC Pharmacol Journal subject: FARMACOLOGIA Year: 2002 Type: Article Affiliation country: United States

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