Designing small, nonsugar activators of antithrombin using hydropathic interaction analyses.

Gunnarsson, Gunnar T; Desai, Umesh R

Gunnarsson, Gunnar T; Desai, Umesh R.

Affiliation

Gunnarsson GT; Department of Medicinal Chemistry, Virginia Commonwealth University, 410 North 12th Street, P.O. Box 980540, Richmond, Virginia 23298, USA.

J Med Chem ; 45(6): 1233-43, 2002 Mar 14.

Article in En | MEDLINE | ID: mdl-11881992

Subject(s)

Antithrombins/agonists; Catechin/chemical synthesis; Drug Design; Enzyme Inhibitors/chemical synthesis; Factor Xa Inhibitors; Sulfuric Acid Esters/chemical synthesis; Carbohydrate Sequence; Catechin/analogs & derivatives; Catechin/chemistry; Catechin/pharmacology; Enzyme Inhibitors/pharmacology; Humans; Models, Molecular; Molecular Sequence Data; Oligosaccharides/chemistry; Oligosaccharides/pharmacology; Protein Conformation; Sulfuric Acid Esters/pharmacology; Surface Properties

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Collection: 01-internacional Database: MEDLINE Main subject: Sulfuric Acid Esters / Drug Design / Catechin / Antithrombins / Enzyme Inhibitors / Factor Xa Inhibitors Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2002 Type: Article Affiliation country: United States

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