Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.

Gibson, G G; Plant, N J; Swales, K E; Ayrton, A; El-Sankary, W

Gibson, G G; Plant, N J; Swales, K E; Ayrton, A; El-Sankary, W.

Affiliation

Gibson GG; Molecular Toxicology Group, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey, UK. g.gibson@surrey.ac.uk

Xenobiotica ; 32(3): 165-206, 2002 Mar.

Article in En | MEDLINE | ID: mdl-11958559

Subject(s)

Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System/genetics; Oxidoreductases, N-Demethylating/genetics; Receptors, Drug/drug effects; Transcriptional Activation/drug effects; Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System/biosynthesis; Enzyme Induction/drug effects; Humans; Isoenzymes/metabolism; Oxidoreductases, N-Demethylating/biosynthesis; Species Specificity; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases, N-Demethylating / Receptors, Drug / Aryl Hydrocarbon Hydroxylases / Transcriptional Activation / Cytochrome P-450 Enzyme System Limits: Animals / Humans Language: En Journal: Xenobiotica Year: 2002 Type: Article Affiliation country: United kingdom

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