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Thinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment.
McLaughlin, Margaret E; Jacks, Tyler.
Affiliation
  • McLaughlin ME; Howard Hughes Medical Institute, Department of Biology and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA.
Cancer Cell ; 1(5): 408-10, 2002 Jun.
Article in En | MEDLINE | ID: mdl-12124168
ABSTRACT
Deletion of both copies of the Nf1 gene in Schwann cells combined with Nf1 heterozygosity in the tumor environment promotes neurofibroma formation in mice.
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Collection: 01-internacional Database: MEDLINE Main subject: Genes, Neurofibromatosis 1 / Gene Deletion / Loss of Heterozygosity / Neurofibroma Limits: Animals / Humans Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2002 Type: Article Affiliation country: United States
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Genes, Neurofibromatosis 1 / Gene Deletion / Loss of Heterozygosity / Neurofibroma Limits: Animals / Humans Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2002 Type: Article Affiliation country: United States