Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics.

Duffy, Kevin J; Price, Alan T; Delorme, Evelyne; Dillon, Susan B; Duquenne, Celine; Erickson-Miller, Connie; Giampa, Leslie; Huang, Yifang; Keenan, Richard M; Lamb, Peter; Liu, Nannan; Miller, Stephen G; Rosen, Jon; Shaw, Anthony N; Smith, Heather; Wiggall, Kenneth J; Zhang, Lihua; Luengo, Juan I

Duffy, Kevin J; Price, Alan T; Delorme, Evelyne; Dillon, Susan B; Duquenne, Celine; Erickson-Miller, Connie; Giampa, Leslie; Huang, Yifang; Keenan, Richard M; Lamb, Peter; Liu, Nannan; Miller, Stephen G; Rosen, Jon; Shaw, Anthony N; Smith, Heather; Wiggall, Kenneth J; Zhang, Lihua; Luengo, Juan I.

J Med Chem ; 45(17): 3576-8, 2002 Aug 15.

Article in En | MEDLINE | ID: mdl-12166929

Subject(s)

Imidazoles/chemical synthesis; Thrombopoietin/chemistry; Antigens, CD34/metabolism; Bone Marrow Cells/drug effects; Bone Marrow Cells/metabolism; Cell Differentiation; Cell Division/drug effects; Cell Line; Combinatorial Chemistry Techniques; Genes, Reporter; Humans; Imidazoles/chemistry; Imidazoles/pharmacology; Luciferases/genetics; Luciferases/metabolism; Models, Molecular; Molecular Mimicry; Phosphorylation; Structure-Activity Relationship; Thrombopoietin/genetics; Thrombopoietin/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Thrombopoietin / Imidazoles Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2002 Type: Article

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