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Prepidil compared to Propess for cervical ripening.
Vollebregt, A; van't Hof, D B; Exalto, N.
Affiliation
  • Vollebregt A; Department of Obstetrics and Gynaecology, Spaarne Ziekenhuis Haarlem, Afdeling Verloskunde en Gynaecologie, Postbus 1644, 2003 Haarlem BR, The Netherlands.
Eur J Obstet Gynecol Reprod Biol ; 104(2): 116-9, 2002 Sep 10.
Article in En | MEDLINE | ID: mdl-12206922
ABSTRACT

OBJECTIVES:

To compare the efficacy and safety of intracervical PGE(2) gel (Prepidil) with intravaginal PGE(2) insert (Propess) in cervical ripening and induction of labour. STUDY

DESIGN:

This was a retrospective analysis of patients with single pregnancies, intact membranes and a viable fetus who required cervical ripening. In the first half of 1998, all patients received Prepidil and in the first half of 1999 all patients received Propess. In both periods 50 consecutive files were retrieved and compared.

RESULTS:

The Prepidil and Propess group were similar in patient characteristics, indication for induction of labour and delivery outcome. Cervical ripening within 24 h was achieved in the Propess group in 80% as compared to 56% in the Prepidil group. The application-membrane rupture-interval was shorter in the Propess group compared to the Prepidil group (23.7 +/- 21.3 h versus 56.4 +/- 77.7 h, P = 0.009) as well as the application-delivery interval (29.8 +/- 22.0 h versus 62.0 +/- 78.8 h, P = 0.039). In the Propess group 62% delivered within 24 h compared to 28% in the Prepidil group. A smaller number of applications was observed in the Propess group (1.2 versus 1.8, P < 0.005). Both methods proved to be safe in cervical priming and no relevant differences in mode of delivery and outcome of labour were detected. None of the patients required an emergency caesarean section during the treatment with prostaglandines.

CONCLUSIONS:

Both prostaglandin E(2) agents are safe and effective in achieving cervical ripening; however the vaginal insert demonstrated a shorter application-delivery interval. The hospital stay was consequently shorter, contributing to cost effectiveness.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Dinoprostone / Cervical Ripening Type of study: Observational_studies Limits: Adult / Female / Humans / Male / Pregnancy Language: En Journal: Eur J Obstet Gynecol Reprod Biol Year: 2002 Type: Article Affiliation country: Netherlands
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Dinoprostone / Cervical Ripening Type of study: Observational_studies Limits: Adult / Female / Humans / Male / Pregnancy Language: En Journal: Eur J Obstet Gynecol Reprod Biol Year: 2002 Type: Article Affiliation country: Netherlands