Conjugation of ligands at the 5'-end of CpG DNA affects immunostimulatory activity.

Kandimalla, Ekambar R; Bhagat, Lakshmi; Yu, Dong; Cong, Yanping; Tang, Jimmy; Agrawal, Sudhir

Kandimalla, Ekambar R; Bhagat, Lakshmi; Yu, Dong; Cong, Yanping; Tang, Jimmy; Agrawal, Sudhir.

Affiliation

Kandimalla ER; Hybridon, Inc., 345 Vassar Street, Cambridge, Massachusetts 02139, USA.

Bioconjug Chem ; 13(5): 966-74, 2002.

Article in En | MEDLINE | ID: mdl-12236778

Subject(s)

Adjuvants, Immunologic/chemical synthesis; Immune System/drug effects; Oligodeoxyribonucleotides/chemical synthesis; Oligodeoxyribonucleotides/immunology; 3' Flanking Region; 5' Flanking Region; Adjuvants, Immunologic/chemistry; Adjuvants, Immunologic/pharmacology; Animals; Cell Line; Cross-Linking Reagents; Cytokines/metabolism; Female; Immune System/cytology; Ligands; Macrophages/drug effects; Macrophages/metabolism; Mice; Mice, Inbred BALB C; NF-kappa B/drug effects; Oligodeoxyribonucleotides/chemistry; Oligonucleotides/chemistry; Oligonucleotides/immunology; Spleen/cytology; Spleen/drug effects; Spleen/metabolism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Oligodeoxyribonucleotides / Adjuvants, Immunologic / Immune System Limits: Animals Language: En Journal: Bioconjug Chem Journal subject: BIOQUIMICA Year: 2002 Type: Article Affiliation country: United States

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