Calcium/calmodulin-dependent kinase II phosphorylation of the GABAA receptor alpha1 subunit modulates benzodiazepine binding.

Churn, Severn B; Rana, Aniruddha; Lee, Kangmin; Parsons, J Travis; De Blas, Angel; Delorenzo, Robert J

Churn, Severn B; Rana, Aniruddha; Lee, Kangmin; Parsons, J Travis; De Blas, Angel; Delorenzo, Robert J.

Affiliation

Churn SB; Department of Neurology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA. SCHURN@HSC.VCU.EDU

J Neurochem ; 82(5): 1065-76, 2002 Sep.

Article in En | MEDLINE | ID: mdl-12358754

Subject(s)

Benzodiazepines/metabolism; Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Protein Subunits; Receptors, GABA-A/metabolism; Allosteric Regulation/physiology; Animals; Benzodiazepines/pharmacokinetics; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases/chemistry; Detergents/chemistry; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation/physiology; Male; Phosphates/metabolism; Phosphorylation; Precipitin Tests; Prosencephalon/chemistry; Protein Binding/physiology; Rats; Rats, Sprague-Dawley; Receptors, GABA-A/chemistry; Synaptosomes/chemistry; Synaptosomes/enzymology

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Collection: 01-internacional Database: MEDLINE Main subject: Benzodiazepines / Calcium-Calmodulin-Dependent Protein Kinases / Receptors, GABA-A / Protein Subunits Limits: Animals Language: En Journal: J Neurochem Year: 2002 Type: Article Affiliation country: United States

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