Molecular imaging and biological evaluation of HuMV833 anti-VEGF antibody: implications for trial design of antiangiogenic antibodies.

Jayson, Gordon C; Zweit, Jamal; Jackson, Alan; Mulatero, Clive; Julyan, Peter; Ranson, Malcolm; Broughton, Lynn; Wagstaff, John; Hakannson, Leif; Groenewegen, Gerard; Bailey, John; Smith, Nigel; Hastings, David; Lawrance, Jeremy; Haroon, Hamied; Ward, Tim; McGown, Alan T; Tang, Meina; Levitt, Dan; Marreaud, Sandrine; Lehmann, Frederic F; Herold, Manfred; Zwierzina, Heinz

Jayson, Gordon C; Zweit, Jamal; Jackson, Alan; Mulatero, Clive; Julyan, Peter; Ranson, Malcolm; Broughton, Lynn; Wagstaff, John; Hakannson, Leif; Groenewegen, Gerard; Bailey, John; Smith, Nigel; Hastings, David; Lawrance, Jeremy; Haroon, Hamied; Ward, Tim; McGown, Alan T; Tang, Meina; Levitt, Dan; Marreaud, Sandrine; Lehmann, Frederic F; Herold, Manfred; Zwierzina, Heinz.

Affiliation

Jayson GC; Cancer Research UK Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, UK. Gordon.Jayson@christie-tr.nwest.nhs.uk

J Natl Cancer Inst ; 94(19): 1484-93, 2002 Oct 02.

Article in En | MEDLINE | ID: mdl-12359857

Subject(s)

Antibodies, Monoclonal/pharmacokinetics; Antibodies, Monoclonal/therapeutic use; Antineoplastic Agents/pharmacokinetics; Antineoplastic Agents/therapeutic use; Endothelial Growth Factors/immunology; Lymphokines/immunology; Magnetic Resonance Imaging/methods; Neoplasms/diagnostic imaging; Neoplasms/therapy; Neovascularization, Pathologic/physiopathology; Animals; Antibodies, Monoclonal, Humanized; Antibody Formation; Capillary Permeability; Dose-Response Relationship, Immunologic; Drug Design; Drug Evaluation, Preclinical; Endothelial Growth Factors/metabolism; Humans; Iodine Radioisotopes; Lymphokines/metabolism; Macaca fascicularis/immunology; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Middle Aged; Neoplasms/blood supply; Neoplasms/immunology; Tissue Distribution; Tomography, Emission-Computed; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Magnetic Resonance Imaging / Endothelial Growth Factors / Lymphokines / Antibodies, Monoclonal / Neoplasms / Neovascularization, Pathologic / Antineoplastic Agents Type of study: Evaluation_studies / Prognostic_studies Limits: Animals / Humans / Middle aged Language: En Journal: J Natl Cancer Inst Year: 2002 Type: Article

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