Clinical experience with linezolid for the treatment of nocardia infection.
Clin Infect Dis
; 36(3): 313-8, 2003 Feb 01.
Article
in En
| MEDLINE
| ID: mdl-12539073
ABSTRACT
Linezolid is an oxazolidinone that has activity against most gram-positive bacteria, including in vitro activity against all Nocardia species and strains. We describe 6 clinical cases of nocardiosis that were successfully treated with linezolid. Two patients had underlying X-linked chronic granulomatous disease, and 2 patients were receiving chronic corticosteroid therapy. Four of 6 patients had disseminated disease, and 2 of these 4 patients had multiple brain abscesses. Four patients primarily received monotherapy; for the fifth patient, linezolid was added to a failing multiple-drug regimen, and, for the sixth patient, it was used as part of combination therapy. All 6 patients were successfully treated, although 1 patient had a presumed relapse of central nervous system infection after premature discontinuation of the drug. Linezolid appears to be an effective alternative for the treatment of nocardiosis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxazolidinones
/
Acetamides
/
Anti-Bacterial Agents
/
Nocardia
/
Nocardia Infections
Limits:
Child
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2003
Type:
Article
Affiliation country:
United States