Human CD38 interferes with HIV-1 fusion through a sequence homologous to the V3 loop of the viral envelope glycoprotein gp120.

Savarino, Andrea; Bensi, Thea; Chiocchetti, Annalisa; Bottarel, Flavia; Mesturini, Riccardo; Ferrero, Enza; Calosso, Liliana; Deaglio, Silvia; Ortolan, Erika; Buttò, Stefano; Cafaro, Aurelio; Katada, Toshiaki; Ensoli, Barbara; Malavasi, Fabio; Dianzani, Umberto

Savarino, Andrea; Bensi, Thea; Chiocchetti, Annalisa; Bottarel, Flavia; Mesturini, Riccardo; Ferrero, Enza; Calosso, Liliana; Deaglio, Silvia; Ortolan, Erika; Buttò, Stefano; Cafaro, Aurelio; Katada, Toshiaki; Ensoli, Barbara; Malavasi, Fabio; Dianzani, Umberto.

Affiliation

Savarino A; Laboratory of Immunology, Interdisciplinary Research Center of Autoimmune Diseases, Department of Medical Science, University of Eastern Piedmont, Novara, Italy. asavarino@medscape.com

FASEB J ; 17(3): 461-3, 2003 Mar.

Article in En | MEDLINE | ID: mdl-12551845

Subject(s)

ADP-ribosyl Cyclase/chemistry; Antigens, CD/chemistry; HIV Envelope Protein gp120/chemistry; HIV Fusion Inhibitors/pharmacology; HIV-1/drug effects; ADP-ribosyl Cyclase/genetics; ADP-ribosyl Cyclase 1; Amino Acid Motifs; Animals; Antigens, CD/genetics; CD4 Antigens/physiology; Cell Line; Down-Regulation; HIV Envelope Protein gp120/metabolism; HIV-1/growth & development; HIV-1/pathogenicity; Humans; Membrane Fusion; Membrane Glycoproteins; Mice; Models, Biological; Peptides/pharmacology; Protein Structure, Tertiary; Receptors, Virus/physiology; Sequence Homology, Amino Acid; Transfection; Virus Replication/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Antigens, CD / HIV Envelope Protein gp120 / HIV-1 / HIV Fusion Inhibitors / ADP-ribosyl Cyclase Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2003 Type: Article Affiliation country: Italy

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