In vitro and in vivo characterization of 3-[2-[6-(2-tert-butoxyethoxy)pyridin-3-yl]-1H-imidazol-4-yl]benzonitrile hydrochloride salt, a potent and selective NPY5 receptor antagonist.

Elliott, Richard L; Oliver, Robert M; Hammond, Marlys; Patterson, Terrell A; She, Li; Hargrove, Diane M; Martin, Kelly A; Maurer, Tristan S; Kalvass, J Cory; Morgan, Bradley P; DaSilva-Jardine, Paul A; Stevenson, Ralph W; Mack, Christine M; Cassella, James V

Elliott, Richard L; Oliver, Robert M; Hammond, Marlys; Patterson, Terrell A; She, Li; Hargrove, Diane M; Martin, Kelly A; Maurer, Tristan S; Kalvass, J Cory; Morgan, Bradley P; DaSilva-Jardine, Paul A; Stevenson, Ralph W; Mack, Christine M; Cassella, James V.

Affiliation

Elliott RL; Cardiovascular and Metabolic Diseases, PGRD, Pfizer Inc., Groton, Connecticut 06340, and Neurogen Corporation, Branford, Connecticut 06405, USA. richard_l_elliot@groton.pfizer.com

J Med Chem ; 46(5): 670-3, 2003 Feb 27.

Article in En | MEDLINE | ID: mdl-12593645

Subject(s)

Imidazoles/chemical synthesis; Nitriles/chemical synthesis; Receptors, Neuropeptide Y/antagonists & inhibitors; Animals; Brain/metabolism; Calcium/metabolism; Cattle; Cerebrospinal Fluid/metabolism; Eating/drug effects; Humans; Imidazoles/pharmacokinetics; Imidazoles/pharmacology; In Vitro Techniques; Male; Nitriles/pharmacokinetics; Nitriles/pharmacology; Pancreatic Polypeptide/pharmacology; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Neuropeptide Y/metabolism; Tissue Distribution; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Neuropeptide Y / Imidazoles / Nitriles Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2003 Type: Article Affiliation country: United States

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