Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo.

Gratton, Jean-Philippe; Yu, Jun; Griffith, Jason W; Babbitt, Roger W; Scotland, Ramona S; Hickey, Reed; Giordano, Frank J; Sessa, William C

Gratton, Jean-Philippe; Yu, Jun; Griffith, Jason W; Babbitt, Roger W; Scotland, Ramona S; Hickey, Reed; Giordano, Frank J; Sessa, William C.

Affiliation

Gratton JP; Department of Pharmacology, Vascular Cell Signaling and Therapeutics Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

Nat Med ; 9(3): 357-62, 2003 Mar.

Article in En | MEDLINE | ID: mdl-12598894

Subject(s)

Gene Transfer Techniques; Nuclear Proteins; Peptides/metabolism; Transcription Factors; Virus Replication/physiology; Adenoviridae/genetics; Adenoviridae/metabolism; Amino Acid Sequence; Animals; Antennapedia Homeodomain Protein; Arteries/cytology; Arteries/metabolism; COS Cells; Fluorescent Dyes/metabolism; Gene Expression Regulation; Genetic Therapy; Hindlimb/blood supply; Homeodomain Proteins/chemistry; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Humans; Ischemia; Molecular Sequence Data; Muscle, Skeletal/metabolism; Nitric Oxide Synthase/genetics; Nitric Oxide Synthase/metabolism; Nitric Oxide Synthase Type III; Peptides/chemistry; Peptides/genetics; Recombinant Fusion Proteins/metabolism; Sequence Alignment

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Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Transcription Factors / Virus Replication / Nuclear Proteins / Gene Transfer Techniques Limits: Animals / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2003 Type: Article Affiliation country: United States

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