Endothelin-1 increases vascular superoxide via endothelin(A)-NADPH oxidase pathway in low-renin hypertension.

Li, Lixin; Fink, Gregory D; Watts, Stephanie W; Northcott, Carrie A; Galligan, James J; Pagano, Patrick J; Chen, Alex F

Li, Lixin; Fink, Gregory D; Watts, Stephanie W; Northcott, Carrie A; Galligan, James J; Pagano, Patrick J; Chen, Alex F.

Affiliation

Li L; Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824-1317, USA.

Circulation ; 107(7): 1053-8, 2003 Feb 25.

Article in En | MEDLINE | ID: mdl-12600921

Subject(s)

Endothelin-1/pharmacology; Hypertension/metabolism; NADPH Oxidases/physiology; Receptors, Endothelin/physiology; Superoxides/metabolism; Animals; Blood Pressure; Carotid Arteries/chemistry; Carotid Arteries/drug effects; Carotid Arteries/metabolism; Desoxycorticosterone; Endothelin Receptor Antagonists; Endothelin-1/metabolism; Hypertension/blood; Hypertension/chemically induced; Hypertension/enzymology; Male; Nitric Oxide Synthase/genetics; Nitric Oxide Synthase/physiology; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Renin/blood; Signal Transduction; Superoxide Dismutase/genetics; Superoxides/analysis; Transduction, Genetic; Xanthine Oxidase/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Endothelin / Superoxides / NADPH Oxidases / Endothelin-1 / Hypertension Limits: Animals Language: En Journal: Circulation Year: 2003 Type: Article Affiliation country: United States

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