Amniotic fluid levels of S100B protein in normal and trisomy-21 foetuses.
Clin Chim Acta
; 330(1-2): 131-3, 2003 Apr.
Article
in En
| MEDLINE
| ID: mdl-12636931
ABSTRACT
BACKGROUND:
The human chromosome 21 has been shown to contain the gene for the beta subunit of the S100B protein. The present case-control study was aimed at investigating whether overproduction of S100B protein is detectable in the amniotic fluid of foetuses with trisomy-21.METHODS:
Measurements of S100B in amniotic fluid samples from 14 pregnant women with trisomy-21 foetuses were compared with those obtained from 182 physiological pregnancies. S100B was measured in the samples using an immunoluminometric assay (LIA-mat Sangtec 100).RESULTS:
Our results showed that S100B protein amniotic fluid levels were significantly higher in trisomy-21 foetuses (0.83+/-0.21 microg/l) than in controls (0.51+/-0.22 microg/l) (p<0.05).CONCLUSION:
The present finding supports the notion that the expression of S100B is increased in trisomy-21 foetuses; it also constitutes a prerequisite basis for a possible involvement of the protein in pathogenic processes associated with trisomy-21, and/or for its potential employment as a diagnostic tool.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromosomes, Human, Pair 21
/
S100 Proteins
/
Down Syndrome
/
Fetus
/
Amniotic Fluid
/
Nerve Growth Factors
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
En
Journal:
Clin Chim Acta
Year:
2003
Type:
Article
Affiliation country:
Italy