ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.
Cell
; 112(6): 819-29, 2003 Mar 21.
Article
in En
| MEDLINE
| ID: mdl-12654248
ABSTRACT
Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thermoreceptors
/
Nociceptors
/
Calcium Channels
/
Cold Temperature
/
Transient Receptor Potential Channels
/
Neurons, Afferent
Limits:
Animals
Language:
En
Journal:
Cell
Year:
2003
Type:
Article
Affiliation country:
United States