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Molecular cytogenetic analysis of a pleuropulmonary blastoma.
Hong, Bo; Chen, Zhong; Coffin, Cheryl M; Lemons, Richard; Issa, Bonnie; Brothman, Arthur; Zhou, Holly.
Affiliation
  • Hong B; Cytogenetics Laboratory, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA.
Cancer Genet Cytogenet ; 142(1): 65-9, 2003 Apr 01.
Article in En | MEDLINE | ID: mdl-12660036
ABSTRACT
We report a case of pleuropulmonary blastoma with complex cytogenetic abnormalities, including trisomy 2, trisomy 8, dup(7), der(10) t(8; 10)(q13; q22), add(17), and double minutes (dmin). Fluorescence in situ hybridization FISH analysis demonstrated TP53 deletion and amplification of MYCN; the latter has not been reported in PPB.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Chromosome Aberrations / Chromosomes, Human / Oncogene Proteins / Pulmonary Blastoma / Lung Neoplasms Limits: Child, preschool / Female / Humans Language: En Journal: Cancer Genet Cytogenet Year: 2003 Type: Article Affiliation country: United States
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Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Chromosome Aberrations / Chromosomes, Human / Oncogene Proteins / Pulmonary Blastoma / Lung Neoplasms Limits: Child, preschool / Female / Humans Language: En Journal: Cancer Genet Cytogenet Year: 2003 Type: Article Affiliation country: United States