Design and synthesis of inhibitors of inducible nitric oxide synthase. Discovery of a new chemical lead with potential for oral bioavailability.

Kawanaka, Yasufumi; Kobayashi, Kaoru; Kusuda, Shinya; Tatsumi, Tadashi; Murota, Masayuki; Nishiyama, Toshihiko; Hisaichi, Katsuya; Fujii, Atsuko; Hirai, Keisuke; Naka, Masao; Komeno, Masaharu; Nakai, Hisao; Toda, Masaaki

Kawanaka, Yasufumi; Kobayashi, Kaoru; Kusuda, Shinya; Tatsumi, Tadashi; Murota, Masayuki; Nishiyama, Toshihiko; Hisaichi, Katsuya; Fujii, Atsuko; Hirai, Keisuke; Naka, Masao; Komeno, Masaharu; Nakai, Hisao; Toda, Masaaki.

Affiliation

Kawanaka Y; Fukui Research Institute, Ono Pharmaceutical Co. Ltd., Technoport, Yamagishi, Mikuni, Fukui 913-8538, Sakai, Japan. kawanaka@ono.co.jp

Eur J Med Chem ; 38(3): 277-88, 2003 Mar.

Article in En | MEDLINE | ID: mdl-12667694

Subject(s)

Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacology; Nitric Oxide Synthase/antagonists & inhibitors; Piperidines/chemical synthesis; Piperidines/pharmacology; Administration, Oral; Animals; Biological Availability; Drug Design; Enzyme Inhibitors/toxicity; Humans; Indicators and Reagents; Isoenzymes/antagonists & inhibitors; Kinetics; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Recombinant Proteins/drug effects; Structure-Activity Relationship; Substrate Specificity; omega-N-Methylarginine/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Nitric Oxide Synthase / Enzyme Inhibitors Limits: Animals / Humans Language: En Journal: Eur J Med Chem Year: 2003 Type: Article Affiliation country: Japan

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