ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs.

Xing, Dezhi; Kjølbye, Anne Louise; Nielsen, Morten S; Petersen, Jørgen S; Harlow, Kenneth W; Holstein-Rathlou, Niels-Henrik; Martins, James B

Xing, Dezhi; Kjølbye, Anne Louise; Nielsen, Morten S; Petersen, Jørgen S; Harlow, Kenneth W; Holstein-Rathlou, Niels-Henrik; Martins, James B.

Affiliation

Xing D; Department of Internal Medicine, University of Iowa College of Medicine and VA Medical Center, Iowa City, Iowa 52242, USA.

J Cardiovasc Electrophysiol ; 14(5): 510-20, 2003 May.

Article in En | MEDLINE | ID: mdl-12776869

Subject(s)

Gap Junctions/drug effects; Myocardial Ischemia/physiopathology; Oligopeptides/therapeutic use; Tachycardia, Ventricular/prevention & control; Tachycardia, Ventricular/physiopathology; Animals; Blood Pressure/physiology; Cell Membrane/drug effects; Cell Membrane/metabolism; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Block/metabolism; Heart Block/physiopathology; Heart Block/prevention & control; Heart Conduction System/drug effects; Heart Conduction System/metabolism; Heart Conduction System/physiopathology; Incidence; Infusions, Intravenous; Male; Models, Cardiovascular; Myocardial Ischemia/metabolism; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/ultrastructure; Oligopeptides/administration & dosage; Oligopeptides/pharmacology; Reproducibility of Results; Statistics as Topic; Tachycardia, Ventricular/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Tachycardia, Ventricular / Myocardial Ischemia / Gap Junctions Type of study: Incidence_studies / Prognostic_studies Limits: Animals Language: En Journal: J Cardiovasc Electrophysiol Journal subject: ANGIOLOGIA / CARDIOLOGIA / FISIOLOGIA Year: 2003 Type: Article Affiliation country: United States

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