Darting behavior: a quantitative movement pattern designed for discrimination and replicability in mouse locomotor behavior.
Behav Brain Res
; 142(1-2): 193-205, 2003 Jun 16.
Article
in En
| MEDLINE
| ID: mdl-12798281
ABSTRACT
In the open-field behavior of rodents, Software for Exploring Exploration (SEE) can be used for an explicit design of behavioral endpoints with high genotype discrimination and replicability across laboratories. This ability is demonstrated here in the development of a measure for darting behavior. The behavior of two common mouse inbred strains, C57BL/6J (B6) and DBA/2J (D2), was analyzed across three different laboratories, and under the effect of cocaine or amphetamine. "Darting" was defined as having higher acceleration during progression segments while moving less during stops. D2 mice darted significantly more than B6 mice in each laboratory, despite being significantly less active. These differences were maintained following cocaine administration (up to 20mg/kg) and only slightly altered by amphetamine (up to 5mg/kg) despite a several fold increase in activity. The replicability of darting behavior was confirmed in additional experiments distinct from those used for its design. The strategy leading to the darting measure may be used to develop additional discriminative and replicable endpoints of open-field behavior.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Software
/
Computational Biology
/
Exploratory Behavior
/
Motor Activity
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Behav Brain Res
Year:
2003
Type:
Article
Affiliation country:
United States