Lopinavir/ritonavir plus saquinavir in salvage therapy; pharmacokinetics, tolerability and efficacy.
AIDS
; 17(11): 1700-2, 2003 Jul 25.
Article
in En
| MEDLINE
| ID: mdl-12853756
ABSTRACT
Patients receiving a lopinavir/ritonavir and saquinavir dual protease inhibitor-based antiretroviral salvage regimen were studied to evaluate the pharmacokinetics, tolerability and efficacy of the regimen. Pharmacokinetic curves were obtained for lopinavir and saquinavir. Patient records were studied for adverse events and efficacy data. The pharmacokinetics of lopinavir and saquinavir were comparable with literature data, except for the saquinavir 0-12 h area under the curve and maximum concentration. The tolerability of the regimen was good and efficacy was encouraging.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrimidinones
/
HIV Infections
/
Ritonavir
/
Saquinavir
/
Anti-HIV Agents
Type of study:
Prognostic_studies
Limits:
Adult
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
AIDS
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Year:
2003
Type:
Article
Affiliation country:
Netherlands