Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory.

Morozov, Alexei; Muzzio, Isabel A; Bourtchouladze, Rusiko; Van-Strien, Niels; Lapidus, Kyle; Yin, DeQi; Winder, Danny G; Adams, J Paige; Sweatt, J David; Kandel, Eric R

Morozov, Alexei; Muzzio, Isabel A; Bourtchouladze, Rusiko; Van-Strien, Niels; Lapidus, Kyle; Yin, DeQi; Winder, Danny G; Adams, J Paige; Sweatt, J David; Kandel, Eric R.

Affiliation

Morozov A; Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA.

Neuron ; 39(2): 309-25, 2003 Jul 17.

Article in En | MEDLINE | ID: mdl-12873387

Subject(s)

Bacterial Proteins; Cyclic AMP/metabolism; Memory/physiology; Mitogen-Activated Protein Kinase 1/physiology; Mitogen-Activated Protein Kinases/physiology; Neuronal Plasticity/genetics; Neuronal Plasticity/physiology; Synapses/metabolism; Valine/analogs & derivatives; rap1 GTP-Binding Proteins/metabolism; Animals; Antirheumatic Agents/pharmacology; Behavior, Animal; Blotting, Western; Colforsin/pharmacology; Conditioning, Psychological; Cues; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; Gene Expression Regulation, Enzymologic; Hippocampus/anatomy & histology; Hippocampus/metabolism; Immunoenzyme Techniques; In Situ Hybridization; Interleukin 1 Receptor Antagonist Protein; Long-Term Potentiation/genetics; Long-Term Potentiation/physiology; Metalloproteins/metabolism; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1/genetics; Mitogen-Activated Protein Kinase 3; Mutation; Prosencephalon/metabolism; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf/metabolism; RNA, Messenger/biosynthesis; Reaction Time; Sialoglycoproteins/pharmacology; Signal Transduction/physiology; Subcellular Fractions/metabolism; Synaptic Transmission/genetics; Synaptic Transmission/physiology; Tetanus; Theta Rhythm; Valine/pharmacology; rap1 GTP-Binding Proteins/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Bacterial Proteins / Valine / Cyclic AMP / Mitogen-Activated Protein Kinase 1 / Rap1 GTP-Binding Proteins / Mitogen-Activated Protein Kinases / Memory / Neuronal Plasticity Language: En Journal: Neuron Journal subject: NEUROLOGIA Year: 2003 Type: Article Affiliation country: United States

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