Herpes simplex encephalitis relapses in children: differentiation of two neurologic entities.

De Tiège, X; Rozenberg, F; Des Portes, V; Lobut, J B; Lebon, P; Ponsot, G; Héron, B

De Tiège, X; Rozenberg, F; Des Portes, V; Lobut, J B; Lebon, P; Ponsot, G; Héron, B.

Affiliation

De Tiège X; Department of Pediatric Neurology, Hôpital Saint Vincent de Paul, Paris, France.

Neurology ; 61(2): 241-3, 2003 Jul 22.

Article in En | MEDLINE | ID: mdl-12874408

ABSTRACT

ABSTRACT

Relapses of herpes simplex encephalitis (HSE) occurring after the completion of antiviral treatment have been reported repeatedly in children. The authors report data on six children who had at least one relapse of HSE. Two different mechanisms may account for these relapses, including viral replication or an immuno-inflammatory process, with different therapeutic attitudes. Relapses with viral replication may reveal host susceptibility to herpes simplex virus infection.

Subject(s)

Encephalitis, Herpes Simplex/classification; Acyclovir/administration & dosage; Acyclovir/therapeutic use; Adolescent; Antiviral Agents/administration & dosage; Antiviral Agents/therapeutic use; Basal Ganglia Diseases/etiology; Child; Child, Preschool; Encephalitis, Herpes Simplex/complications; Encephalitis, Herpes Simplex/drug therapy; Female; Follow-Up Studies; Humans; Infant; Male; Recurrence; Retrospective Studies

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Collection: 01-internacional Database: MEDLINE Main subject: Encephalitis, Herpes Simplex Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Neurology Year: 2003 Type: Article Affiliation country: France

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