Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells.

Swales, K; Plant, N; Ayrton, A; Hood, S; Gibson, G

Swales, K; Plant, N; Ayrton, A; Hood, S; Gibson, G.

Affiliation

Swales K; School of Biomedial and Life Sciences, University of Surrey, Guildford, UK.

Xenobiotica ; 33(7): 703-16, 2003 Jul.

Article in En | MEDLINE | ID: mdl-12893520

Subject(s)

Aryl Hydrocarbon Hydroxylases/genetics; Aryl Hydrocarbon Hydroxylases/metabolism; Carcinoma, Hepatocellular/enzymology; Carcinoma, Hepatocellular/genetics; Gene Expression Regulation, Enzymologic/genetics; Oxidoreductases, N-Demethylating/genetics; Oxidoreductases, N-Demethylating/metabolism; Transcription Factors/metabolism; Animals; Aryl Hydrocarbon Hydroxylases/drug effects; Cell Line, Tumor; Cytochrome P-450 CYP3A; Dexamethasone/pharmacology; Dose-Response Relationship, Drug; Gene Expression Profiling; Gene Expression Regulation, Enzymologic/drug effects; Humans; Liver Neoplasms/enzymology; Liver Neoplasms/genetics; Oxidoreductases, N-Demethylating/drug effects; Pregnane X Receptor; Rats; Receptors, Cytoplasmic and Nuclear/metabolism; Receptors, Steroid/metabolism; Rifampin/pharmacology; Species Specificity; Tissue Distribution; Transcription Factors/genetics

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases, N-Demethylating / Transcription Factors / Aryl Hydrocarbon Hydroxylases / Gene Expression Regulation, Enzymologic / Carcinoma, Hepatocellular Limits: Animals / Humans Language: En Journal: Xenobiotica Year: 2003 Type: Article Affiliation country: United kingdom

Search on Google

XML

PubMed Links