Varicella-zoster virus infection in adult patients after unrelated cord blood transplantation: a single institute experience in Japan.
Br J Haematol
; 122(5): 802-5, 2003 Sep.
Article
in En
| MEDLINE
| ID: mdl-12930392
ABSTRACT
Varicella-zoster virus (VZV) infection was studied in 40 adult patients who underwent cord blood transplantation (CBT) from unrelated donors. Twenty-five patients developed VZV reactivation at a median of 5 months after CBT (range 1.7-26 months). The cumulative incidence of VZV reactivation after CBT was 80% at 30 months. Twenty-two patients developed localized herpes zoster. The remaining three patients developed atypical non-localized herpes zoster, which was associated with visceral dissemination in one patient. All the patients responded well to antiviral therapy. Unexpectedly, the absence of grade II-IV acute graft-versus-host disease (GVHD) was associated with a higher rate of VZV reactivation after CBT (100% versus 55%, P=0.01). These results suggest that recovery of VZV-specific immune responses after CBT is delayed even in patients without severe acute GVHD.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Activation
/
Herpesvirus 3, Human
/
Cord Blood Stem Cell Transplantation
/
Hematologic Diseases
/
Herpes Zoster
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Br J Haematol
Year:
2003
Type:
Article
Affiliation country:
Japan