Enhanced cell killing induced by the combination of radiation and the heat shock protein 90 inhibitor 17-allylamino-17- demethoxygeldanamycin: a multitarget approach to radiosensitization.

Russell, Jeffery S; Burgan, William; Oswald, Kelli A; Camphausen, Kevin; Tofilon, Philip J

Russell, Jeffery S; Burgan, William; Oswald, Kelli A; Camphausen, Kevin; Tofilon, Philip J.

Affiliation

Russell JS; Molecular Radiation Therapeutics Branch, Radiation Oncology Science Program, National Cancer Institute, Bethesda, Maryland 20892, USA.

Clin Cancer Res ; 9(10 Pt 1): 3749-55, 2003 Sep 01.

Article in En | MEDLINE | ID: mdl-14506167

Subject(s)

HSP90 Heat-Shock Proteins/antagonists & inhibitors; Radiation-Sensitizing Agents/pharmacology; Radiotherapy/methods; Rifabutin/analogs & derivatives; Rifabutin/pharmacology; Benzoquinones; Cell Cycle; Cell Death; Cell Line; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Fibroblasts/metabolism; Humans; Immunoblotting; Lactams, Macrocyclic; Radiation Tolerance; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Radiation-Sensitizing Agents / Radiotherapy / Rifabutin / HSP90 Heat-Shock Proteins Limits: Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2003 Type: Article Affiliation country: United States

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