The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents.
Bioorg Med Chem Lett
; 13(21): 3759-63, 2003 Nov 03.
Article
in En
| MEDLINE
| ID: mdl-14552774
ABSTRACT
The naturally occurring aurone 1, isolated from Uvaria hamiltonii, and a series of aurones analogues based structurally on known tubulin binding agents were prepared and evaluated for anticancer activity. Aurone 20 was the most active (IC(50) K562 50 nM) and caused significant G2/M cell-cycle arrest.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Benzofurans
/
Flavonoids
/
Uvaria
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2003
Type:
Article
Affiliation country:
United kingdom