Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.

Bisht, Kheem S; Bradbury, C Matthew; Mattson, David; Kaushal, Aradhana; Sowers, Anastasia; Markovina, Stephanie; Ortiz, Karen L; Sieck, Leah K; Isaacs, Jennifer S; Brechbiel, Martin W; Mitchell, James B; Neckers, Leonard M; Gius, David

Bisht, Kheem S; Bradbury, C Matthew; Mattson, David; Kaushal, Aradhana; Sowers, Anastasia; Markovina, Stephanie; Ortiz, Karen L; Sieck, Leah K; Isaacs, Jennifer S; Brechbiel, Martin W; Mitchell, James B; Neckers, Leonard M; Gius, David.

Affiliation

Bisht KS; Radiation Oncology Branch and. Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-1002, USA.

Cancer Res ; 63(24): 8984-95, 2003 Dec 15.

Article in En | MEDLINE | ID: mdl-14695217

Subject(s)

Antibiotics, Antineoplastic/pharmacology; HSP90 Heat-Shock Proteins/physiology; Quinones/pharmacology; Radiation-Sensitizing Agents/pharmacology; Rifabutin/analogs & derivatives; Rifabutin/pharmacology; Uterine Cervical Neoplasms/drug therapy; Uterine Cervical Neoplasms/radiotherapy; Animals; Benzoquinones; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Synergism; Female; HeLa Cells; Humans; Lactams, Macrocyclic; Mice; Mice, Inbred C3H; Mice, Nude; Signal Transduction/drug effects; Xenograft Model Antitumor Assays

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Collection: 01-internacional Database: MEDLINE Main subject: Quinones / Radiation-Sensitizing Agents / Uterine Cervical Neoplasms / Rifabutin / HSP90 Heat-Shock Proteins / Antibiotics, Antineoplastic Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cancer Res Year: 2003 Type: Article Affiliation country: United States

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