A CD4(+) T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease.

Reece, William H H; Pinder, Margaret; Gothard, Philip K; Milligan, Paul; Bojang, Kalifa; Doherty, Tom; Plebanski, Magdalena; Akinwunmi, Peter; Everaere, Simone; Watkins, Katherine R; Voss, Gerald; Tornieporth, Nadia; Alloueche, Ali; Greenwood, Brian M; Kester, Kent E; McAdam, Keith P W J; Cohen, Joe; Hill, Adrian V S

Reece, William H H; Pinder, Margaret; Gothard, Philip K; Milligan, Paul; Bojang, Kalifa; Doherty, Tom; Plebanski, Magdalena; Akinwunmi, Peter; Everaere, Simone; Watkins, Katherine R; Voss, Gerald; Tornieporth, Nadia; Alloueche, Ali; Greenwood, Brian M; Kester, Kent E; McAdam, Keith P W J; Cohen, Joe; Hill, Adrian V S.

Affiliation

Reece WH; Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.

Nat Med ; 10(4): 406-10, 2004 Apr.

Article in En | MEDLINE | ID: mdl-15034567

Subject(s)

CD4-Positive T-Lymphocytes/immunology; Epitopes/immunology; Malaria, Falciparum/prevention & control; Protozoan Proteins/immunology; Adolescent; Adult; Amino Acid Sequence; Conserved Sequence; Enzyme-Linked Immunosorbent Assay; Humans; Immunologic Memory; Malaria, Falciparum/immunology; Middle Aged; Molecular Sequence Data

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Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Protozoan Proteins / Malaria, Falciparum / Epitopes Type of study: Prognostic_studies Limits: Adolescent / Adult / Humans / Middle aged Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2004 Type: Article Affiliation country: United kingdom

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