Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.

Wan, Paul T C; Garnett, Mathew J; Roe, S Mark; Lee, Sharlene; Niculescu-Duvaz, Dan; Good, Valerie M; Jones, C Michael; Marshall, Christopher J; Springer, Caroline J; Barford, David; Marais, Richard

Wan, Paul T C; Garnett, Mathew J; Roe, S Mark; Lee, Sharlene; Niculescu-Duvaz, Dan; Good, Valerie M; Jones, C Michael; Marshall, Christopher J; Springer, Caroline J; Barford, David; Marais, Richard.

Affiliation

Wan PT; Section of Structural Biology, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.

Cell ; 116(6): 855-67, 2004 Mar 19.

Article in En | MEDLINE | ID: mdl-15035987

Subject(s)

Cell Transformation, Neoplastic/genetics; MAP Kinase Signaling System/genetics; Mitogen-Activated Protein Kinases/genetics; Mutation/genetics; Oncogenes/genetics; Proto-Oncogene Proteins c-raf/genetics; Allosteric Regulation/genetics; Animals; Catalytic Domain/genetics; Enzyme Inhibitors/pharmacology; Gene Expression Regulation, Enzymologic/genetics; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases/genetics; Mitogen-Activated Protein Kinase Kinases/metabolism; Models, Molecular; Molecular Conformation; NIH 3T3 Cells; Neoplasms/enzymology; Neoplasms/genetics; Oocytes; Phosphorylation; Phosphotransferases/genetics; Phosphotransferases/metabolism; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf/antagonists & inhibitors; Proto-Oncogene Proteins c-raf/metabolism; Up-Regulation/genetics; Xenopus

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Collection: 01-internacional Database: MEDLINE Main subject: Oncogenes / Cell Transformation, Neoplastic / Proto-Oncogene Proteins c-raf / Mitogen-Activated Protein Kinases / MAP Kinase Signaling System / Mutation Limits: Animals Language: En Journal: Cell Year: 2004 Type: Article Affiliation country: United kingdom

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